Zinc isotopic compositions of breast cancer tissue

Hdl Handle:
http://hdl.handle.net/10141/620608
Title:
Zinc isotopic compositions of breast cancer tissue
Authors:
Larner, F; Woodley, LN; Shousha, S; Moyes, A; Halliday, AN; Rehkaemper, M ( 0000-0002-0075-9872 ) ; Coombes, RC; Strekopytov, Stanislav ( 0000-0001-5129-9880 ) ; Humphreys-Williams, Emma ( 0000-0002-1397-5785 )
Abstract:
An early diagnostic biomarker for breast cancer is essential to improve outcome. High precision isotopic analysis, originating in Earth sciences, can detect very small shifts in metal pathways. For the first time, the natural intrinsic Zn isotopic compositions of various tissues in breast cancer patients and controls were determined. Breast cancer tumours were found to have a significantly lighter Zn isotopic composition than the blood, serum and healthy breast tissue in both groups. The Zn isotopic lightness in tumours suggests that sulphur rich metallothionein dominates the isotopic selectivity of a breast tissue cell, rather than Zn-specific proteins. This reveals a possible mechanism of Zn delivery to Zn-sequestering vesicles by metallothionein, and is supported by a similar signature observed in the copper isotopic compositions of one breast cancer patient. This change in intrinsic isotopic compositions due to cancer has the potential to provide a novel early biomarker for breast cancer.
Citation:
Larner F, Woodley LN, Shousha S et al. Zinc isotopic compositions of breast cancer tissue. Metallomics 7, 112–117 (2015).
Publisher:
The Royal Society of Chemistry
Journal:
Metallomics
Issue date:
1-Dec-2014
URI:
http://hdl.handle.net/10141/620608
DOI:
10.1039/c4mt00260a
Submitted date:
2016-03-31
Type:
Journal Article
ISSN:
1756-5901
Appears in Collections:
Core research labs and consulting

Full metadata record

DC FieldValue Language
dc.contributor.authorLarner, Fen
dc.contributor.authorWoodley, LNen
dc.contributor.authorShousha, Sen
dc.contributor.authorMoyes, Aen
dc.contributor.authorHalliday, ANen
dc.contributor.authorRehkaemper, Men
dc.contributor.authorCoombes, RCen
dc.contributor.authorStrekopytov, Stanislaven
dc.contributor.authorHumphreys-Williams, Emmaen
dc.date.accessioned2016-09-21T10:34:11Z-
dc.date.available2016-09-21T10:34:11Z-
dc.date.issued2014-12-01-
dc.date.submitted2016-03-31-
dc.identifier.citationLarner F, Woodley LN, Shousha S et al. Zinc isotopic compositions of breast cancer tissue. Metallomics 7, 112–117 (2015).en
dc.identifier.issn1756-5901-
dc.identifier.doi10.1039/c4mt00260a-
dc.identifier.urihttp://hdl.handle.net/10141/620608-
dc.descriptionThis article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. https://creativecommons.org/licenses/by-nc-nd/3.0/ The attached file is the published version of the article.en
dc.description.abstractAn early diagnostic biomarker for breast cancer is essential to improve outcome. High precision isotopic analysis, originating in Earth sciences, can detect very small shifts in metal pathways. For the first time, the natural intrinsic Zn isotopic compositions of various tissues in breast cancer patients and controls were determined. Breast cancer tumours were found to have a significantly lighter Zn isotopic composition than the blood, serum and healthy breast tissue in both groups. The Zn isotopic lightness in tumours suggests that sulphur rich metallothionein dominates the isotopic selectivity of a breast tissue cell, rather than Zn-specific proteins. This reveals a possible mechanism of Zn delivery to Zn-sequestering vesicles by metallothionein, and is supported by a similar signature observed in the copper isotopic compositions of one breast cancer patient. This change in intrinsic isotopic compositions due to cancer has the potential to provide a novel early biomarker for breast cancer.en
dc.language.isoenen
dc.publisherThe Royal Society of Chemistryen
dc.rightsThis article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/-
dc.subjectDiagnostic biomarkeren
dc.subjectIsotopic analysisen
dc.subjectBreast Canceren
dc.titleZinc isotopic compositions of breast cancer tissueen
dc.typeJournal Articleen
dc.identifier.journalMetallomicsen
dc.identifier.volume7en
dc.identifier.issue1en
dc.identifier.startpage112-117en
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