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dc.contributor.authorLarner, F
dc.contributor.authorWoodley, LN
dc.contributor.authorShousha, S
dc.contributor.authorMoyes, A
dc.contributor.authorHalliday, AN
dc.contributor.authorRehkämper, M
dc.contributor.authorCoombes, RC
dc.contributor.authorStrekopytov, S
dc.contributor.authorHumphreys-Williams, Emma
dc.date.accessioned2016-09-21T10:34:11Z
dc.date.available2016-09-21T10:34:11Z
dc.date.issued2014-12-01
dc.date.submitted2016-03-31
dc.identifier.citationLarner F, Woodley LN, Shousha S et al. Zinc isotopic compositions of breast cancer tissue. Metallomics 7, 112–117 (2015).en
dc.identifier.issn1756-5901
dc.identifier.doi10.1039/c4mt00260a
dc.identifier.urihttp://hdl.handle.net/10141/620608
dc.descriptionThis article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. https://creativecommons.org/licenses/by-nc-nd/3.0/ The attached file is the published version of the article.en
dc.description.abstractAn early diagnostic biomarker for breast cancer is essential to improve outcome. High precision isotopic analysis, originating in Earth sciences, can detect very small shifts in metal pathways. For the first time, the natural intrinsic Zn isotopic compositions of various tissues in breast cancer patients and controls were determined. Breast cancer tumours were found to have a significantly lighter Zn isotopic composition than the blood, serum and healthy breast tissue in both groups. The Zn isotopic lightness in tumours suggests that sulphur rich metallothionein dominates the isotopic selectivity of a breast tissue cell, rather than Zn-specific proteins. This reveals a possible mechanism of Zn delivery to Zn-sequestering vesicles by metallothionein, and is supported by a similar signature observed in the copper isotopic compositions of one breast cancer patient. This change in intrinsic isotopic compositions due to cancer has the potential to provide a novel early biomarker for breast cancer.
dc.language.isoenen
dc.publisherThe Royal Society of Chemistryen
dc.relation.isreplacedby10141/622173
dc.relation.isreplacedbyhttp://hdl.handle.net/10141/622173
dc.rightsThis article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.
dc.rightsOpenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subjectDiagnostic biomarkeren
dc.subjectIsotopic analysisen
dc.subjectBreast Canceren
dc.titleZinc isotopic compositions of breast cancer tissueen
dc.typeJournal Articleen
dc.identifier.journalMetallomicsen
dc.identifier.volume7en
dc.identifier.issue1en
dc.identifier.startpage112-117en
dc.internal.reviewer-noteopen access. HCL working on; 3.0 license.en
pubs.organisational-group/Natural History Museumen
pubs.organisational-group/Natural History Museum/Science Groupen
pubs.organisational-group/Natural History Museum/Science Group/Core Research Laboratoriesen
pubs.organisational-group/Natural History Museum/Science Group/Core Research Laboratories/Imaging and Analysis Centre (IAC)en
pubs.organisational-group/Natural History Museum/Science Group/Functional groupsen
pubs.organisational-group/Natural History Museum/Science Group/Functional groups/Facilities Supporten
dc.embargoNot knownen_US
dc.description.nhmThis article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. https://creativecommons.org/licenses/by-nc-nd/3.0/ The attached file is the published version of the article.
dc.subject.nhmDiagnostic biomarker; Isotopic analysis; Breast Cancer
refterms.dateFOA2019-03-01T08:47:06Z
html.description.abstractAn early diagnostic biomarker for breast cancer is essential to improve outcome. High precision isotopic analysis, originating in Earth sciences, can detect very small shifts in metal pathways. For the first time, the natural intrinsic Zn isotopic compositions of various tissues in breast cancer patients and controls were determined. Breast cancer tumours were found to have a significantly lighter Zn isotopic composition than the blood, serum and healthy breast tissue in both groups. The Zn isotopic lightness in tumours suggests that sulphur rich metallothionein dominates the isotopic selectivity of a breast tissue cell, rather than Zn-specific proteins. This reveals a possible mechanism of Zn delivery to Zn-sequestering vesicles by metallothionein, and is supported by a similar signature observed in the copper isotopic compositions of one breast cancer patient. This change in intrinsic isotopic compositions due to cancer has the potential to provide a novel early biomarker for breast cancer.


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