Evolutionary recruitment of flexible Esrp-dependent splicing programs into diverse embryonic morphogenetic processes
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Authors
Burguera, DMarquez, Y
Racioppi, C
Permanyer, J
Torres-Mendez, A
Esposito, R
Albuixech-Crespo, B
Fanlo, L
D'Agostino, Y
Gohr, A
Navas-Perez, E
Riesgo, A
Cuomo, C
Benvenuto, G
Christiaen, LA
Marti, E
D'Aniello, S
Spagnuolo, A
Ristoratore, F
Arnone, MI
Garcia-Fernandez, J
Irimia, M
Issue date
2017-12Submitted date
2018-01-11Subject Terms
Evolutionary developmental biologyTranscriptomics
Epithelial-mesenchymal interactions
Morphogenetic evolution
Esrp genes
Vetebrates
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Show full item recordAbstract
Epithelial-mesenchymal interactions are crucial for the development of numerous animal structures. Thus, unraveling how molecular tools are recruited in different lineages to control interplays between these tissues is key to understanding morphogenetic evolution. Here, we study Esrp genes, which regulate extensive splicing programs and are essential for mammalian organogenesis. We find that Esrp homologs have been independently recruited for the development of multiple structures across deuterostomes. Although Esrp is involved in a wide variety of ontogenetic processes, our results suggest ancient roles in non-neural ectoderm and regulating specific mesenchymal-to-epithelial transitions in deuterostome ancestors. However, consistent with the extensive rewiring of Esrp-dependent splicing programs between phyla, most developmental defects observed in vertebrate mutants are related to other types of morphogenetic processes. This is likely connected to the origin of an event in Fgfr, which was recruited as an Esrp target in stem chordates and subsequently co-opted into the development of many novel traits in vertebrates.Citation
Burguera D, Marquez Y, Racioppi C, Permanyer J, Torres-mendez A, Esposito R, Albuixech-crespo B, Fanlo L, D'agostino Y, Gohr A, Navas-perez E, Riesgo A, Cuomo C, Benvenuto G, Christiaen LA, Marti E, D'aniello S, Spagnuolo A, Ristoratore F, Arnone MI, Garcia-fernandez J, Irimia M (2017) Evolutionary recruitment of flexible Esrp-dependent splicing programs into diverse embryonic morphogenetic processes. NATURE COMMUNICATIONS, 8 : doi: 10.1038/s41467-017-01961-yJournal
Nature CommunicationsType
Journal ArticleItem Description
© The Author(s) 2017. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.NHM Repository
EISSN
2041-1723ae974a485f413a2113503eed53cd6c53
10.1038/s41467-017-01961-y
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