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Reconstruction of the diapsid ancestral genome permits chromosome evolution tracing in avian and non-avian dinosaurs

dc.contributor.authorO'Connor, RE
dc.contributor.authorRomanov, MN
dc.contributor.authorKiazim, LG
dc.contributor.authorBarrett, PM
dc.contributor.authorFarré, M
dc.contributor.authorDamas, J
dc.contributor.authorFerguson-Smith, M
dc.contributor.authorValenzuela, N
dc.contributor.authorLarkin, DM
dc.contributor.authorGriffin, DK
dc.date.accessioned2018-06-05T14:24:00Z
dc.date.available2018-06-05T14:24:00Z
dc.date.issued21/05/2018en
dc.date.submitted2018-05-31
dc.identifier.citationTY - JOUR AU - O’Connor, Rebecca E. AU - Romanov, Michael N. AU - Kiazim, Lucas G. AU - Barrett, Paul M. AU - Farré, Marta AU - Damas, Joana AU - Ferguson-Smith, Malcolm AU - Valenzuela, Nicole AU - Larkin, Denis M. AU - Griffin, Darren K. PY - 2018 DA - 2018/05/21 TI - Reconstruction of the diapsid ancestral genome permits chromosome evolution tracing in avian and non-avian dinosaurs JO - Nature Communications SP - 1883 VL - 9 IS - 1 AB - Genomic organisation of extinct lineages can be inferred from extant chromosome-level genome assemblies. Here, we apply bioinformatic and molecular cytogenetic approaches to determine the genomic structure of the diapsid common ancestor. We then infer the events that likely occurred along this lineage from theropod dinosaurs through to modern birds. Our results suggest that most elements of a typical ‘avian-like’ karyotype (40 chromosome pairs, including 30 microchromosomes) were in place before the divergence of turtles from birds ~255 mya. This genome organisation therefore predates the emergence of early dinosaurs and pterosaurs and the evolution of flight. Remaining largely unchanged interchromosomally through the dinosaur–theropod route that led to modern birds, intrachromosomal changes nonetheless reveal evolutionary breakpoint regions enriched for genes with ontology terms related to chromatin organisation and transcription. This genomic structure therefore appears highly stable yet contributes to a large degree of phenotypic diversity, as well as underpinning adaptive responses to major environmental disruptions via intrachromosomal repatterning. SN - 2041-1723 UR - https://doi.org/10.1038/s41467-018-04267-9 DO - 10.1038/s41467-018-04267-9 ID - O’Connor2018en
dc.identifier.doi10.1038/s41467-018-04267-9en_US
dc.identifier.urihttp://hdl.handle.net/10141/622371
dc.relation.urihttps://www.nature.com/articles/s41467-018-04267-9?WT.ec_id=NCOMMS-20180523&spMailingID=56673545&spUserID=ODkwMTM2NjQyNgS2&spJobID=1403493766&spReportId=MTQwMzQ5Mzc2NgS2en_US
dc.rightsopenAccessen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleReconstruction of the diapsid ancestral genome permits chromosome evolution tracing in avian and non-avian dinosaursen_US
dc.typeJournal Article
dc.identifier.eissn2041-1723en_US
dc.identifier.journalNature Communicationsen_US
dc.identifier.volume9en_US
dc.identifier.issue1en_US
dc.internal.reviewer-noteReviewed LorP 5Jun2018en
pubs.organisational-group/Natural History Museum
pubs.organisational-group/Natural History Museum/Science Group
pubs.organisational-group/Natural History Museum/Science Group/Earth Sciences
pubs.organisational-group/Natural History Museum/Science Group/Earth Sciences/Vertebrates and Anthropology Palaeobiology
pubs.organisational-group/Natural History Museum/Science Group/Functional groups
pubs.organisational-group/Natural History Museum/Science Group/Functional groups/Research
dc.embargoNot knownen_US
elements.import.authorO’Connor, REen_US
elements.import.authorRomanov, MNen_US
elements.import.authorKiazim, LGen_US
elements.import.authorBarrett, PMen_US
elements.import.authorFarré, Men_US
elements.import.authorDamas, Jen_US
elements.import.authorFerguson-Smith, Men_US
elements.import.authorValenzuela, Nen_US
elements.import.authorLarkin, DMen_US
elements.import.authorGriffin, DKen_US
dc.description.nhmThe file attached is the Published/publisher’s pdf version of the article.en
dc.description.nhmOpen Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
dc.description.nhmNHM Repository
dc.subject.nhmComparative genomics; evolutionary biology; evolutionary genetics
refterms.dateFOA2018-12-13T13:55:56Z


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