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dc.contributor.authorSchumann, I
dc.contributor.authorKenny, NJ
dc.contributor.authorHui, J
dc.contributor.authorHering, L
dc.contributor.authorMeyer, G
dc.date.accessioned2019-03-12T14:44:54Z
dc.date.available2019-03-12T14:44:54Z
dc.date.issued2018-09-12
dc.date.submitted2019-01-31
dc.identifier.citationSchumann I, Kenny N, Hui J, Hering L, Mayer G. 2018 Halloween genes in panarthropods and the evolution of the early moulting pathway in Ecdysozoa. R. Soc. open sci. 5: 180888. http://dx.doi.org/10.1098/rsos.180888en_US
dc.identifier.doi10.1098/rsos.180888
dc.identifier.urihttp://hdl.handle.net/10141/622438
dc.description.abstractMoulting is a characteristic feature of Ecdysozoa—the clade of moulting animals that includes the hyperdiverse arthropods and less speciose groups, such as onychophorans, tardigrades and nematodes. Moulting has been best analysed in arthropods, specifically in insects and crustaceans, in which a complex neuroendocrine system acts at the genomic level and initiates the transcription of genes responsible for moulting. The key moulting hormones, ecdysone and 20-hydroxyecdysone, are subsequently synthesized from cholesterol ingested with food. Their biosynthesis is regulated by the Rieske-domain protein Neverland and cytochrome P450 enzymes encoded by the so-called ‘Halloween’ genes. Ecdysone is then released into the haemolymph and modified into 20-hydroxyecdysone, which binds to the nuclear receptor EcR/USP and initiates transcription of the Early genes. As little is known about the moulting pathway of other ecdysozoans, we examined the occurrence of genes involved in ecdysteroid biosynthesis and the early moulting cascade across ecdysozoan subgroups. Genomic and transcriptomic searches revealed no Halloween genes in cycloneuralians, whereas only shadow (CYP315A1) is present in onychophorans and tardigrades, suggesting that the Halloween genes evolved stepwise in panarthropods. These findings imply that the genes which were responsible for the ecdysteroid biosynthesis in the last common ancestor of Ecdysozoa are currently unknown.en_US
dc.publisherThe Royal Societyen_US
dc.rightsopenAccessen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleHalloween genes in panarthropods and the evolution of the early moulting pathway in Ecdysozoaen_US
dc.typeJournal Articleen_US
dc.identifier.journalRoyal Society Open Scienceen_US
pubs.organisational-group/Natural History Museum
pubs.organisational-group/Natural History Museum/Science Group
pubs.organisational-group/Natural History Museum/Science Group/Functional groups
pubs.organisational-group/Natural History Museum/Science Group/Functional groups/Other Support
pubs.organisational-group/Natural History Museum/Science Group/Life Sciences
dc.embargoNot knownen_US
elements.import.authorSchumann, Ien_US
elements.import.authorKenny, NJen_US
elements.import.authorHui, Jen_US
elements.import.authorHering, Len_US
elements.import.authorMeyer, Gen_US
dc.description.nhm& 2018 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited. The attached file is the published version of this article.en_US
dc.subject.nhm20-hydroxyecdysoneen_US
dc.subject.nhmHalloween genesen_US
dc.subject.nhmecdysisen_US
dc.subject.nhmecdysoneen_US
dc.subject.nhmOnychophoraen_US
dc.subject.nhmTardigradaen_US
refterms.dateFOA2019-03-12T14:44:54Z


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