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dc.contributor.authorHuyse, T
dc.contributor.authorWebster, BL
dc.contributor.authorGeldof, S
dc.contributor.authorStothard, JR
dc.contributor.authorDiaw, OT
dc.contributor.authorPolman, K
dc.contributor.authorRollinson, D
dc.contributor.editorKazura, JWen_US
dc.date.accessioned2019-04-12T10:49:17Z
dc.date.available2019-04-12T10:49:17Z
dc.date.issued2009-09-04
dc.date.submitted2018-01-31
dc.identifier.citationHuyse T, Webster BL, Geldof S, Stothard JR, Diaw OT, et al. (2009) Bidirectional Introgressive Hybridization between a Cattle and Human Schistosome Species. PLoS Pathog 5(9): e1000571. doi:10.1371/journal.ppat.1000571en_US
dc.identifier.doi10.1371/journal.ppat.1000571
dc.identifier.urihttp://hdl.handle.net/10141/622478
dc.description.abstractSchistosomiasis is a disease of great medical and veterinary importance in tropical and subtropical regions, caused by parasitic flatworms of the genus Schistosoma (subclass Digenea). Following major water development schemes in the 1980s, schistosomiasis has become an important parasitic disease of children living in the Senegal River Basin (SRB). During molecular parasitological surveys, nuclear and mitochondrial markers revealed unexpected natural interactions between a bovine and human Schistosoma species: S. bovis and S. haematobium, respectively. Hybrid schistosomes recovered from the urine and faeces of children and the intermediate snail hosts of both parental species, Bulinus truncatus and B. globosus, presented a nuclear ITS rRNA sequence identical to S. haematobium, while the partial mitochondrial cox1 sequence was identified as S. bovis. Molecular data suggest that the hybrids are not 1st generation and are a result of parental and/or hybrid backcrosses, indicating a stable hybrid zone. Larval stages with the reverse genetic profile were also found and are suggested to be F1 progeny. The data provide indisputable evidence for the occurrence of bidirectional introgressive hybridization between a bovine and a human Schistosoma species. Hybrid species have been found infecting B. truncatus, a snail species that is now very abundant throughout the SRB. The recent increase in urinary schistosomiasis in the villages along the SRB could therefore be a direct effect of the increased transmission through B. truncatus. Hybridization between schistosomes under laboratory conditions has been shown to result in heterosis (higher fecundity, faster maturation time, wider intermediate host spectrum), having important implications on disease prevalence, pathology and treatment. If this new hybrid exhibits the same hybrid vigour, it could develop into an emerging pathogen, necessitating further control strategies in zones where both parental species overlap.en_US
dc.publisherPLOSen_US
dc.relation.urihttp://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1000571en_US
dc.rightsopenAccessen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleBidirectional Introgressive Hybridization between a Cattle and Human Schistosome Speciesen_US
dc.typeJournal Articleen_US
dc.identifier.eissn1553-7374
dc.identifier.journalPLoS Pathogensen_US
dc.identifier.volume5en_US
dc.identifier.issue9en_US
dc.identifier.startpagee1000571 - e1000571en_US
pubs.organisational-group/Natural History Museum
pubs.organisational-group/Natural History Museum/Science Group
pubs.organisational-group/Natural History Museum/Science Group/Functional groups
pubs.organisational-group/Natural History Museum/Science Group/Functional groups/Research
pubs.organisational-group/Natural History Museum/Science Group/Functional groups/Research/LS Research
pubs.organisational-group/Natural History Museum/Science Group/Life Sciences
pubs.organisational-group/Natural History Museum/Science Group/Life Sciences/Parasites and Vectors
pubs.organisational-group/Natural History Museum/Science Group/Life Sciences/Parasites and Vectors/Parasites and Vectors - Research
dc.embargoNot knownen_US
elements.import.authorHuyse, Ten_US
elements.import.authorWebster, BLen_US
elements.import.authorGeldof, Sen_US
elements.import.authorStothard, JRen_US
elements.import.authorDiaw, OTen_US
elements.import.authorPolman, Ken_US
elements.import.authorRollinson, Den_US
dc.description.nhmCopyright 2009 Huyse et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_US
dc.subject.nhmSchistosomiasisen_US
dc.subject.nhmParasitic flatwormsen_US
dc.subject.nhmParasitic diseaseen_US
dc.subject.nhmHybridizationen_US
refterms.dateFOA2019-04-12T10:49:18Z


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