Show simple item record

dc.contributor.authorKnopp, S
dc.contributor.authorAme, SM
dc.contributor.authorPerson, B
dc.contributor.authorHattendorf, J
dc.contributor.authorRabone, M
dc.contributor.authorJuma, S
dc.contributor.authorMuhsin, J
dc.contributor.authorKhamis, IS
dc.contributor.authorHollenberg, E
dc.contributor.authorMohammed, KA
dc.contributor.authorKabole, F
dc.contributor.authorAli, SM
dc.contributor.authorRollinson, D
dc.date.accessioned2020-03-10T15:53:02Z
dc.date.available2020-03-10T15:53:02Z
dc.date.issued2019-05-06
dc.date.submitted2019-10-29
dc.identifier.citationKnopp S, Ame SM, Person B, Hattendorf J, Rabone M, Juma S, et al. (2019) A 5-Year intervention study on elimination of urogenital schistosomiasis in Zanzibar: Parasitological results of annual cross-sectional surveys. PLoS Negl Trop Dis 13(5): e0007268. https://doi.org/10.1371/journal.pntd.0007268en_US
dc.identifier.doi10.1371/journal.pntd.0007268
dc.identifier.urihttp://hdl.handle.net/10141/622638
dc.description.abstractBackground The Zanzibar Elimination of Schistosomiasis Transmission (ZEST) project aimed to eliminate urogenital schistosomiasis as a public health problem from Pemba and to interrupt Schistosoma haematobium transmission from Unguja in 5 years. Methodology A repeated cross-sectional cluster-randomized trial was implemented from 2011/12 till 2017. On each island, 45 shehias were randomly assigned to receive one of three interventions: biannual mass drug administration (MDA) with praziquantel alone, or in combination with snail control or behavior change measures. In cross-sectional surveys, a single urine sample was collected from ~9,000 students aged 9- to 12-years and from ~4,500 adults aged 20- to 55-years annually, and from ~9,000 1st year students at baseline and the final survey. Each sample was examined for S. haematobium eggs by a single urine filtration. Prevalence and infection intensity were determined. Odds of infection were compared between the intervention arms. Principal findings Prevalence was reduced from 6.1% (95% confidence interval (CI): 4.5%-7.6%) to 1.7% (95% CI: 1.2%-2.2%) in 9- to 12-year old students, from 3.9% (95% CI: 2.8%-5.0%) to 1.5% (95% CI: 1.0%-2.0%) in adults, and from 8.8% (95% CI: 6.5%-11.2%) to 2.6% (95% CI: 1.7%-3.5%) in 1st year students from 2011/12 to 2017. In 2017, heavy infection intensities occurred in 0.4% of 9- to 12-year old students, 0.1% of adults, and 0.8% of 1st year students. Considering 1st year students in 2017, 13/45 schools in Pemba and 4/45 schools in Unguja had heavy infection intensities >1%. There was no significant difference in prevalence between the intervention arms in any study group and year. Conclusions/Significance Urogenital schistosomiasis was eliminated as public health problem from most sites in Pemba and Unguja. Prevalence was significantly reduced, but transmission was not interrupted. Continued interventions that are adaptive and tailored to the micro-epidemiology of S. haematobium in Zanzibar are needed to sustain and advance the gains made by ZEST.en_US
dc.language.isoenen_US
dc.publisherPublic Library of Science (PLoS)en_US
dc.relation.urihttps://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0007268&type=printableen_US
dc.rightsopenAccessen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleA 5-Year intervention study on elimination of urogenital schistosomiasis in Zanzibar: Parasitological results of annual cross-sectional surveysen_US
dc.typeJournal Articleen_US
dc.identifier.eissn1935-2735
dc.identifier.journalPLOS Neglected Tropical Diseasesen_US
dc.identifier.volume13en_US
dc.identifier.issue5en_US
dc.identifier.startpagee0007268 - e0007268en_US
pubs.organisational-group/Natural History Museum
pubs.organisational-group/Natural History Museum/Science Group
pubs.organisational-group/Natural History Museum/Science Group/Functional groups
pubs.organisational-group/Natural History Museum/Science Group/Functional groups/Facilities Support
pubs.organisational-group/Natural History Museum/Science Group/Life Sciences
pubs.organisational-group/Natural History Museum/Science Group/Life Sciences/Parasites and Vectors
dc.embargoNot knownen_US
elements.import.authorKnopp, Sen_US
elements.import.authorAme, SMen_US
elements.import.authorPerson, Ben_US
elements.import.authorHattendorf, Jen_US
elements.import.authorRabone, Men_US
elements.import.authorJuma, Sen_US
elements.import.authorMuhsin, Jen_US
elements.import.authorKhamis, ISen_US
elements.import.authorHollenberg, Een_US
elements.import.authorMohammed, KAen_US
elements.import.authorKabole, Fen_US
elements.import.authorAli, SMen_US
elements.import.authorRollinson, Den_US
dc.description.nhm© 2019 Knopp et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The attached file is the published pdf.en_US
dc.description.nhmNHM Repository
dc.subject.nhmSchistosoma haematobiumen_US
dc.subject.nhmSchoolsen_US
dc.subject.nhmUrineen_US
dc.subject.nhmTanzaniaen_US
dc.subject.nhmSnailsen_US
dc.subject.nhmurogenital schistosomiasisen_US
dc.subject.nhmPublic healthen_US
refterms.dateFOA2020-03-10T15:53:02Z


Files in this item

Thumbnail
Name:
Knopp_et_al_2019_a_5-year_inte ...
Size:
3.224Mb
Format:
PDF
Description:
Published/publisher's PDF version
Thumbnail
Name:
pntd.0007268.s001.pdf
Size:
15.68Kb
Format:
PDF
Description:
Supporting information
Thumbnail
Name:
pntd.0007268.s002.pdf
Size:
30.16Kb
Format:
PDF
Description:
Supporting information
Thumbnail
Name:
pntd.0007268.s003.xlsx
Size:
13.63Kb
Format:
Microsoft Excel 2007
Description:
Supporting information
Thumbnail
Name:
pntd.0007268.s004.pdf
Size:
35.65Kb
Format:
PDF
Description:
Supporting information

This item appears in the following Collection(s)

Show simple item record

openAccess
Except where otherwise noted, this item's license is described as openAccess