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dc.contributor.authorPhilippe, H
dc.contributor.authorBrinkmann, H
dc.contributor.authorLavrov, DV
dc.contributor.authorLittlewood, T
dc.contributor.authorManuel, M
dc.contributor.authorWörheide, G
dc.contributor.authorBaurain, D
dc.date.accessioned2020-03-23T12:57:12Z
dc.date.available2020-03-23T12:57:12Z
dc.date.issued2011-03-15
dc.date.submitted2020-03-04
dc.identifier.citationPhilippe H, Brinkmann H, Lavrov DV, Littlewood DTJ, Manuel M, Wörheide G, et al. (2011) Resolving Difficult Phylogenetic Questions: Why More Sequences Are Not Enough. PLoS Biol 9(3): e1000602. https://doi.org/10.1371/journal.pbio.1000602en_US
dc.identifier.doi10.1371/journal.pbio.1000602
dc.identifier.urihttp://hdl.handle.net/10141/622646
dc.description.abstractIn the quest to reconstruct the Tree of Life, researchers have increasingly turned to phylogenomics, the inference of phylogenetic relationships using genome-scale data (Box 1). Mesmerized by the sustained increase in sequencing throughput, many phylogeneticists entertained the hope that the incongruence frequently observed in studies using single or a few genes [1] would come to an end with the generation of large multigene datasets. Yet, as so often happens, reality has turned out to be far more complex, as three recent large-scale analyses, one published in PLoS Biology [2–4], make clear. The studies, which deal with the early diversification of animals, produced highly incongruent (Box 2) findings despite the use of considerable sequence data (see Figure 1). Clearly, merely adding more sequences is not enough to resolve the inconsistencies. Here, taking these three studies as a case in point, we discuss pitfalls that the simple addition of sequences cannot avoid, and show how the observed incongruence can be largely overcome and how improved bioinformatics methods can help reveal the full potential of phylogenomics.en_US
dc.language.isoenen_US
dc.publisherPublic Library of Science (PLoS)en_US
dc.rightsopenAccessen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleResolving Difficult Phylogenetic Questions: Why More Sequences Are Not Enoughen_US
dc.typeJournal Articleen_US
dc.identifier.eissn1545-7885
dc.identifier.journalPLoS Biologyen_US
dc.identifier.volume9en_US
dc.identifier.issue3en_US
dc.identifier.startpagee1000602 - e1000602en_US
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dc.embargoNot knownen_US
elements.import.authorPhilippe, Hen_US
elements.import.authorBrinkmann, Hen_US
elements.import.authorLavrov, DVen_US
elements.import.authorLittlewood, DTJen_US
elements.import.authorManuel, Men_US
elements.import.authorWörheide, Gen_US
elements.import.authorBaurain, Den_US
dc.description.nhm© 2011 Philippe et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The attached file is the published pdf.en_US
dc.subject.nhmAnimal phylogeneticsen_US
dc.subject.nhmPhylogenetic analysisen_US
dc.subject.nhmPhylogeneticsen_US
dc.subject.nhmSequence alignmenten_US
dc.subject.nhmMultiple alignment calculationen_US
dc.subject.nhmEvolutionary geneticsen_US
dc.subject.nhmSpongesen_US
dc.subject.nhmSpecies diversityen_US
refterms.dateFOA2020-03-23T12:57:12Z


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