Bidirectional Introgressive Hybridization between a Cattle and Human Schistosome Species
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Bidirectional introgressive ...
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Authors
Huyse, TineWebster, BL

Geldof, Sarah
Stothard, J Russell
Diaw, Oumar T
Polman, Katja
Rollinson, D

Issue date
2009-09-04Submitted date
2009-06-11Subject Terms
Schistosoma haematobiumSchistosoma
eggs
parasitic diseases
hybridization
Schistosoma mansoni
urine
schistosomiasis
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Show full item recordAbstract
Schistosomiasis is a disease of great medical and veterinary importance in tropical and subtropical regions, caused by parasitic flatworms of the genus Schistosoma (subclass Digenea). Following major water development schemes in the 1980s, schistosomiasis has become an important parasitic disease of children living in the Senegal River Basin (SRB). During molecular parasitological surveys, nuclear and mitochondrial markers revealed unexpected natural interactions between a bovine and human Schistosoma species: S. bovis and S. haematobium, respectively. Hybrid schistosomes recovered from the urine and faeces of children and the intermediate snail hosts of both parental species, Bulinus truncatus and B. globosus, presented a nuclear ITS rRNA sequence identical to S. haematobium, while the partial mitochondrial cox1 sequence was identified as S. bovis. Molecular data suggest that the hybrids are not 1st generation and are a result of parental and/or hybrid backcrosses, indicating a stable hybrid zone. Larval stages with the reverse genetic profile were also found and are suggested to be F1 progeny. The data provide indisputable evidence for the occurrence of bidirectional introgressive hybridization between a bovine and a human Schistosoma species. Hybrid species have been found infecting B. truncatus, a snail species that is now very abundant throughout the SRB. The recent increase in urinary schistosomiasis in the villages along the SRB could therefore be a direct effect of the increased transmission through B. truncatus. Hybridization between schistosomes under laboratory conditions has been shown to result in heterosis (higher fecundity, faster maturation time, wider intermediate host spectrum), having important implications on disease prevalence, pathology and treatment. If this new hybrid exhibits the same hybrid vigour, it could develop into an emerging pathogen, necessitating further control strategies in zones where both parental species overlap.Citation
Huyse T, Webster BL, Geldof S, Stothard JR, Diaw OT, et al.(2009) Bidirectional Introgressive Hybridization between a Cattle and Human Schistosome Species. PLoSPathog5(9):e1000571.doi:10.1371/journal.ppat.1000571Publisher
Public Library of Science (PLoS)Journal
PLoS PathogensType
Journal ArticleItem Description
Copyright © 2009 Huyse et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The attached file is the published version of the article.ISSN
1553-7366EISSN
1553-7374ae974a485f413a2113503eed53cd6c53
10.1371/journal.ppat.1000571
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