Genetic Diversity within Schistosoma haematobium: DNA Barcoding Reveals Two Distinct Groups
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Genetic diversity within Schis ...
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Authors
Webster, BL
Emery, AM

Webster, Joanne P
Gouvras, Anouk
Garba, Amadou
Diaw, Oumar
Seye, Mohmoudane M
Tchuente, Louis Albert Tchuem
Simoonga, Christopher
Mwanga, Joseph
Lange, Charles
Kariuki, Curtis
Mohammed, Khalfan A
Stothard, J Russell
Rollinson, D

Issue date
2012-10-25Submitted date
2012-05-11Subject Terms
haplotypespopulation genetics
Schistosoma haematobium
species diversity
Tanzania
Africa
islands
Indian Ocean
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Show full item recordAbstract
Background - Schistosomiasis in one of the most prevalent parasitic diseases, affecting millions of people and animals in developing countries. Amongst the human-infective species S. haematobium is one of the most widespread causing urogenital schistosomiasis, a major human health problem across Africa, however in terms of research this human pathogen has been severely neglected. Methodology/principal findings - To elucidate the genetic diversity of Schistosoma haematobium, a DNA 'barcoding' study was performed on parasite material collected from 41 localities representing 18 countries across Africa and the Indian Ocean Islands. Surprisingly low sequence variation was found within the mitochondrial cytochrome oxidase subunit I (cox1) and the NADH-dehydrogenase subunit 1 snad1). The 61 haplotypes found within 1978 individual samples split into two distinct groups; one (Group 1) that is predominately made up of parasites from the African mainland and the other (Group 2) that is made up of samples exclusively from the Indian Ocean Islands and the neighbouring African coastal regions. Within Group 1 there was a dominance of one particular haplotype (H1) representing 1574 (80%) of the samples analyzed. Population genetic diversity increased in samples collected from the East African coastal regions and the data suggest that there has been movement of parasites between these areas and the Indian Ocean Islands. Conclusions/significance - The high occurrence of the haplotype (H1) suggests that at some point in the recent evolutionary history of S. haematobium in Africa the population may have passed through a genetic 'bottleneck' followed by a population expansion. This study provides novel and extremely interesting insights into the population genetics of S. haematobium on a large geographic scale, which may have consequence for control and monitoring of urogenital schistosomiasis.Citation
Webster BL, Emery AM, Webster JP, Gouvras A , Garba A, et al. (2012) Genetic Diversity within Schistosoma haematobium: DNA Barcoding Reveals Two Distinct Groups. PLoS Negl Trop Dis 6(10): e1882. doi:10.1371/journal.pntd.0001882Publisher
Public Library of Science (PLoS)Journal
PLoS Neglected Tropical DiseasesType
Journal ArticleItem Description
Copyright: © 2012 Webster et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The attached file is the published version of the article.ISSN
1935-2735EISSN
1935-2735ae974a485f413a2113503eed53cd6c53
10.1371/journal.pntd.0001882
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