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dc.contributor.authorWebster, BL
dc.contributor.authorEmery, AM
dc.contributor.authorWebster, Joanne P
dc.contributor.authorGouvras, Anouk
dc.contributor.authorGarba, Amadou
dc.contributor.authorDiaw, Oumar
dc.contributor.authorSeye, Mohmoudane M
dc.contributor.authorTchuente, Louis Albert Tchuem
dc.contributor.authorSimoonga, Christopher
dc.contributor.authorMwanga, Joseph
dc.contributor.authorLange, Charles
dc.contributor.authorKariuki, Curtis
dc.contributor.authorMohammed, Khalfan A
dc.contributor.authorStothard, J Russell
dc.contributor.authorRollinson, D
dc.date.accessioned2022-06-22T10:25:37Z
dc.date.available2022-06-22T10:25:37Z
dc.date.issued2012-10-25
dc.date.submitted2012-05-11
dc.identifier.citationWebster BL, Emery AM, Webster JP, Gouvras A , Garba A, et al. (2012) Genetic Diversity within Schistosoma haematobium: DNA Barcoding Reveals Two Distinct Groups. PLoS Negl Trop Dis 6(10): e1882. doi:10.1371/journal.pntd.0001882en_US
dc.identifier.issn1935-2735
dc.identifier.doi10.1371/journal.pntd.0001882
dc.identifier.urihttp://hdl.handle.net/10141/623001
dc.descriptionWebster, Bonnie L. Emery, Aiden M. Webster, Joanne P. Gouvras, Anouk Garba, Amadou Diaw, Oumar Seye, Mohmoudane M. Tchuente, Louis Albert Tchuem Simoonga, Christopher Mwanga, Joseph Lange, Charles Kariuki, Curtis Mohammed, Khalfan A. Stothard, J. Russell Rollinson, Daviden_US
dc.description.abstractBackground - Schistosomiasis in one of the most prevalent parasitic diseases, affecting millions of people and animals in developing countries. Amongst the human-infective species S. haematobium is one of the most widespread causing urogenital schistosomiasis, a major human health problem across Africa, however in terms of research this human pathogen has been severely neglected. Methodology/principal findings - To elucidate the genetic diversity of Schistosoma haematobium, a DNA 'barcoding' study was performed on parasite material collected from 41 localities representing 18 countries across Africa and the Indian Ocean Islands. Surprisingly low sequence variation was found within the mitochondrial cytochrome oxidase subunit I (cox1) and the NADH-dehydrogenase subunit 1 snad1). The 61 haplotypes found within 1978 individual samples split into two distinct groups; one (Group 1) that is predominately made up of parasites from the African mainland and the other (Group 2) that is made up of samples exclusively from the Indian Ocean Islands and the neighbouring African coastal regions. Within Group 1 there was a dominance of one particular haplotype (H1) representing 1574 (80%) of the samples analyzed. Population genetic diversity increased in samples collected from the East African coastal regions and the data suggest that there has been movement of parasites between these areas and the Indian Ocean Islands. Conclusions/significance - The high occurrence of the haplotype (H1) suggests that at some point in the recent evolutionary history of S. haematobium in Africa the population may have passed through a genetic 'bottleneck' followed by a population expansion. This study provides novel and extremely interesting insights into the population genetics of S. haematobium on a large geographic scale, which may have consequence for control and monitoring of urogenital schistosomiasis.en_US
dc.language.isoenen_US
dc.publisherPublic Library of Science (PLoS)en_US
dc.rightsopenAccessen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleGenetic Diversity within Schistosoma haematobium: DNA Barcoding Reveals Two Distinct Groupsen_US
dc.typeJournal Articleen_US
dc.identifier.eissn1935-2735
dc.identifier.journalPLoS Neglected Tropical Diseasesen_US
dc.date.updated2022-06-17T15:56:06Z
dc.identifier.volume6en_US
dc.identifier.issue10en_US
dc.identifier.startpagee1882-e1882en_US
elements.import.authorWebster, Bonnie L
elements.import.authorEmery, Aiden M
elements.import.authorWebster, Joanne P
elements.import.authorGouvras, Anouk
elements.import.authorGarba, Amadou
elements.import.authorDiaw, Oumar
elements.import.authorSeye, Mohmoudane M
elements.import.authorTchuente, Louis Albert Tchuem
elements.import.authorSimoonga, Christopher
elements.import.authorMwanga, Joseph
elements.import.authorLange, Charles
elements.import.authorKariuki, Curtis
elements.import.authorMohammed, Khalfan A
elements.import.authorStothard, J Russell
elements.import.authorRollinson, David
dc.description.nhmCopyright: © 2012 Webster et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The attached file is the published version of the article.en_US
dc.subject.nhmhaplotypesen_US
dc.subject.nhmpopulation geneticsen_US
dc.subject.nhmSchistosoma haematobiumen_US
dc.subject.nhmspecies diversityen_US
dc.subject.nhmTanzaniaen_US
dc.subject.nhmAfricaen_US
dc.subject.nhmislandsen_US
dc.subject.nhmIndian Oceanen_US
refterms.dateFOA2022-06-22T10:25:38Z


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