Parasite Population Genetic Contributions to the Schistosomiasis Consortium for Operational Research and Evaluation within Sub-Saharan Africa
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Authors
Webster, Joanne PNeves, Maria Inês
Webster, BL

Pennance, T

Rabone, M

Gouvras, A

Allan, F

Walker, Martin
Rollinson, D

Issue date
2020-05-12Submitted date
2019-11-06
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Show full item recordAbstract
Analyses of the population genetic structure of schistosomes under the "Schistosomiasis Consortium for Operational Research and Evaluation" (SCORE) contrasting treatment pressure scenarios in Tanzania, Niger, and Zanzibar were performed to provide supplementary critical information with which to evaluate the impact of these large-scale control activities and guide how activities could be adjusted. We predicted that population genetic analyses would reveal information on a range of important parameters including, but not exclusive to, recruitment and transmission of genotypes, occurrence of hybridization events, differences in reproductive mode, and degrees of inbreeding, and hence, the evolutionary potential, and responses of parasite populations under contrasting treatment pressures. Key findings revealed that naturally high levels of gene flow and mixing of the parasite populations between neighboring sites were likely to dilute any effects imposed by the SCORE treatment arms. Furthermore, significant inherent differences in parasite fecundity were observed, independent of current treatment arm, but potentially of major impact in terms of maintaining high levels of ongoing transmission in persistent "biological hotspot" sites. Within Niger, naturally occurring <i>Schistosoma haematobium/Schistosoma bovis</i> viable hybrids were found to be abundant, often occurring in significantly higher proportions than that of single-species <i>S. haematobium</i> infections. By examining parasite population genetic structures across hosts, treatment regimens, and the spatial landscape, our results to date illustrate key transmission processes over and above that which could be achieved through standard parasitological monitoring of prevalence and intensity alone, as well as adding to our understanding of <i>Schistosoma</i> spp. life history strategies in general.Citation
Webster JP, Neves MI, Webster BL, et al. Parasite Population Genetic Contributions to the Schistosomiasis Consortium for Operational Research and Evaluation within Sub-Saharan Africa. The American Journal of Tropical Medicine and Hygiene. 2020;103(1_Suppl):80-91. doi:10.4269/ajtmh.19-0827Type
Journal ArticleItem Description
Copyright © 2020 by The American Society of Tropical Medicine and Hygiene. The attached file is the published version of the article.ISSN
0002-9637EISSN
1476-1645ae974a485f413a2113503eed53cd6c53
10.4269/ajtmh.19-0827
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