• Login
    View Item 
    •   Home
    • Science
    • Life sciences
    • View Item
    •   Home
    • Science
    • Life sciences
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of The Natural History Museum repositoryCommunitiesTitleAuthorsIssue dateAvailable dateSubjectsTypesJournalPublisherThis CollectionTitleAuthorsIssue dateAvailable dateSubjectsTypesJournalPublisher

    My Account

    Login

    About

    AboutOur scienceDepartments and staffCollectionsLibrary and ArchivesContact usCreative Commons Attribution 2.0 LicenseGetting Started

    Statistics

    Display statistics

    Parasite Population Genetic Contributions to the Schistosomiasis Consortium for Operational Research and Evaluation within Sub-Saharan Africa

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    Parasite Population Genetic ...
    Size:
    1.293Mb
    Format:
    PDF
    Description:
    Published Version
    Download
    Average rating
     
       votes
    Cast your vote
    You can rate an item by clicking the amount of stars they wish to award to this item. When enough users have cast their vote on this item, the average rating will also be shown.
    Star rating
     
    Your vote was cast
    Thank you for your feedback
    Authors
    Webster, Joanne P
    Neves, Maria Inês
    Webster, BL cc
    Pennance, T cc
    Rabone, M cc
    Gouvras, A cc
    Allan, F cc
    Walker, Martin
    Rollinson, D cc
    Issue date
    2020-05-12
    Submitted date
    2019-11-06
    
    Metadata
    Show full item record
    Abstract
    Analyses of the population genetic structure of schistosomes under the "Schistosomiasis Consortium for Operational Research and Evaluation" (SCORE) contrasting treatment pressure scenarios in Tanzania, Niger, and Zanzibar were performed to provide supplementary critical information with which to evaluate the impact of these large-scale control activities and guide how activities could be adjusted. We predicted that population genetic analyses would reveal information on a range of important parameters including, but not exclusive to, recruitment and transmission of genotypes, occurrence of hybridization events, differences in reproductive mode, and degrees of inbreeding, and hence, the evolutionary potential, and responses of parasite populations under contrasting treatment pressures. Key findings revealed that naturally high levels of gene flow and mixing of the parasite populations between neighboring sites were likely to dilute any effects imposed by the SCORE treatment arms. Furthermore, significant inherent differences in parasite fecundity were observed, independent of current treatment arm, but potentially of major impact in terms of maintaining high levels of ongoing transmission in persistent "biological hotspot" sites. Within Niger, naturally occurring <i>Schistosoma haematobium/Schistosoma bovis</i> viable hybrids were found to be abundant, often occurring in significantly higher proportions than that of single-species <i>S. haematobium</i> infections. By examining parasite population genetic structures across hosts, treatment regimens, and the spatial landscape, our results to date illustrate key transmission processes over and above that which could be achieved through standard parasitological monitoring of prevalence and intensity alone, as well as adding to our understanding of <i>Schistosoma</i> spp. life history strategies in general.
    Citation
    Webster JP, Neves MI, Webster BL, et al. Parasite Population Genetic Contributions to the Schistosomiasis Consortium for Operational Research and Evaluation within Sub-Saharan Africa. The American Journal of Tropical Medicine and Hygiene. 2020;103(1_Suppl):80-91. doi:10.4269/ajtmh.19-0827
    Publisher
    American Society of Tropical Medicine and Hygiene
    Journal
    The American Journal of Tropical Medicine and Hygiene
    URI
    http://hdl.handle.net/10141/623002
    DOI
    10.4269/ajtmh.19-0827
    Type
    Journal Article
    Item Description
    Copyright © 2020 by The American Society of Tropical Medicine and Hygiene. The attached file is the published version of the article.
    ISSN
    0002-9637
    EISSN
    1476-1645
    ae974a485f413a2113503eed53cd6c53
    10.4269/ajtmh.19-0827
    Scopus Count
    Collections
    Life sciences

    entitlement

     

    DSpace software (copyright © 2002 - 2022)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export button (to the right?) will allow you to export the search results of the entered query to a CSV file. To export the items, click the "Export" button.

    There are two options to select the items you want to export to a CSV. Either you export all results from a search query, or you select a subset of items from the search results.

    To select a subset of the search results, click "Selective Export" in the Export menu.

    After making a selection, click the 'CSV' button. The amount of items that will be exported is indicated in the bubble next to 'CSV'.

    The amount of items you can export is limited, but authenticating will increase this limit.