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dc.contributor.authorWebster, Joanne P
dc.contributor.authorNeves, Maria Inês
dc.contributor.authorWebster, BL
dc.contributor.authorPennance, T
dc.contributor.authorRabone, M
dc.contributor.authorGouvras, A
dc.contributor.authorAllan, F
dc.contributor.authorWalker, Martin
dc.contributor.authorRollinson, D
dc.date.accessioned2022-06-22T11:25:23Z
dc.date.available2022-06-22T11:25:23Z
dc.date.issued2020-05-12
dc.date.submitted2019-11-06
dc.identifier.citationWebster JP, Neves MI, Webster BL, et al. Parasite Population Genetic Contributions to the Schistosomiasis Consortium for Operational Research and Evaluation within Sub-Saharan Africa. The American Journal of Tropical Medicine and Hygiene. 2020;103(1_Suppl):80-91. doi:10.4269/ajtmh.19-0827en_US
dc.identifier.issn0002-9637
dc.identifier.doi10.4269/ajtmh.19-0827
dc.identifier.urihttp://hdl.handle.net/10141/623002
dc.description.abstractAnalyses of the population genetic structure of schistosomes under the "Schistosomiasis Consortium for Operational Research and Evaluation" (SCORE) contrasting treatment pressure scenarios in Tanzania, Niger, and Zanzibar were performed to provide supplementary critical information with which to evaluate the impact of these large-scale control activities and guide how activities could be adjusted. We predicted that population genetic analyses would reveal information on a range of important parameters including, but not exclusive to, recruitment and transmission of genotypes, occurrence of hybridization events, differences in reproductive mode, and degrees of inbreeding, and hence, the evolutionary potential, and responses of parasite populations under contrasting treatment pressures. Key findings revealed that naturally high levels of gene flow and mixing of the parasite populations between neighboring sites were likely to dilute any effects imposed by the SCORE treatment arms. Furthermore, significant inherent differences in parasite fecundity were observed, independent of current treatment arm, but potentially of major impact in terms of maintaining high levels of ongoing transmission in persistent "biological hotspot" sites. Within Niger, naturally occurring <i>Schistosoma haematobium/Schistosoma bovis</i> viable hybrids were found to be abundant, often occurring in significantly higher proportions than that of single-species <i>S. haematobium</i> infections. By examining parasite population genetic structures across hosts, treatment regimens, and the spatial landscape, our results to date illustrate key transmission processes over and above that which could be achieved through standard parasitological monitoring of prevalence and intensity alone, as well as adding to our understanding of <i>Schistosoma</i> spp. life history strategies in general.en_US
dc.language.isoenen_US
dc.publisherAmerican Society of Tropical Medicine and Hygieneen_US
dc.rightsopenAccessen_US
dc.titleParasite Population Genetic Contributions to the Schistosomiasis Consortium for Operational Research and Evaluation within Sub-Saharan Africaen_US
dc.typeJournal Articleen_US
dc.identifier.eissn1476-1645
dc.identifier.journalThe American Journal of Tropical Medicine and Hygieneen_US
dc.date.updated2022-06-17T16:03:23Z
dc.identifier.volume103en_US
dc.identifier.issue1_Supplen_US
dc.identifier.startpage80-91en_US
elements.import.authorWebster, Joanne P
elements.import.authorNeves, Maria Inês
elements.import.authorWebster, Bonnie L
elements.import.authorPennance, Tom
elements.import.authorRabone, Muriel
elements.import.authorGouvras, Anouk N
elements.import.authorAllan, Fiona
elements.import.authorWalker, Martin
elements.import.authorRollinson, David
dc.description.nhmCopyright © 2020 by The American Society of Tropical Medicine and Hygiene. The attached file is the published version of the article.en_US
refterms.dateFOA2022-06-22T11:25:24Z


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