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dc.contributor.authorRey, Olivier
dc.contributor.authorToulza, Eve
dc.contributor.authorChaparro, Cristian
dc.contributor.authorAllienne, Jean-François
dc.contributor.authorKincaid-Smith, Julien
dc.contributor.authorMathieu-Begné, Eglantine
dc.contributor.authorAllan, F
dc.contributor.authorRollinson, D
dc.contributor.authorWebster, BL
dc.contributor.authorBoissier, Jérôme
dc.date.accessioned2022-06-22T13:49:15Z
dc.date.available2022-06-22T13:49:15Z
dc.date.issued2021-02-05
dc.date.submitted2020-06-18
dc.identifier.citationRey O, Toulza E, Chaparro C, Allienne J-F, Kincaid-Smith J, Mathieu-Begne´ E, et al. (2021) Diverging patterns of introgression from Schistosoma bovis across S. haematobium African lineages. PLoS Pathog 17(2): e1009313. https:// doi.org/10.1371/journal.ppat.1009313en_US
dc.identifier.issn1553-7366
dc.identifier.doi10.1371/journal.ppat.1009313
dc.identifier.urihttp://hdl.handle.net/10141/623004
dc.description.abstractHybridization is a fascinating evolutionary phenomenon that raises the question of how species maintain their integrity. Inter-species hybridization occurs between certain Schistosoma species that can cause important public health and veterinary issues. In particular hybrids between Schistosoma haematobium and S. bovis associated with humans and animals respectively are frequently identified in Africa. Recent genomic evidence indicates that some S. haematobium populations show signatures of genomic introgression from S. bovis. Here, we conducted a genomic comparative study and investigated the genomic relationships between S. haematobium, S. bovis and their hybrids using 19 isolates originating from a wide geographical range over Africa, including samples initially classified as S. haematobium (n = 11), S. bovis (n = 6) and S. haematobium x S. bovis hybrids (n = 2). Based on a whole genomic sequencing approach, we developed 56,181 SNPs that allowed a clear differentiation of S. bovis isolates from a genomic cluster including all S. haematobium isolates and a natural S. haematobium-bovis hybrid. All the isolates from the S. haematobium cluster except the isolate from Madagascar harbored signatures of genomic introgression from S. bovis. Isolates from Corsica, Mali and Egypt harbored the S. bovis-like Invadolysin gene, an introgressed tract that has been previously detected in some introgressed S. haematobium populations from Niger. Together our results highlight the fact that introgression from S. bovis is widespread across S. haematobium and that the observed introgression is unidirectional.en_US
dc.language.isoenen_US
dc.publisherPublic Library of Science (PLoS)en_US
dc.rightsopenAccessen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleDiverging patterns of introgression from Schistosoma bovis across S. haematobium African lineagesen_US
dc.typeJournal Articleen_US
dc.identifier.eissn1553-7374
dc.identifier.journalPLOS Pathogensen_US
dc.date.updated2022-06-17T15:53:37Z
dc.identifier.volume17en_US
dc.identifier.issue2en_US
dc.identifier.startpagee1009313-e1009313en_US
elements.import.authorRey, Olivier
elements.import.authorToulza, Eve
elements.import.authorChaparro, Cristian
elements.import.authorAllienne, Jean-François
elements.import.authorKincaid-Smith, Julien
elements.import.authorMathieu-Begné, Eglantine
elements.import.authorAllan, Fiona
elements.import.authorRollinson, David
elements.import.authorWebster, Bonnie L
elements.import.authorBoissier, Jérôme
dc.description.nhmCopyright: © 2021 Rey et al. This is an open access article distributed under the terms of the Creative CommonsAttribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The attached file is the published version of the article.en_US
dc.subject.nhmSchistosoma haematobiumen_US
dc.subject.nhmgenomicsen_US
dc.subject.nhmintrogressionen_US
dc.subject.nhmsingle nucleotide polymorphismsen_US
dc.subject.nhmprincipal component analysisen_US
dc.subject.nhmgenome analysisen_US
dc.subject.nhminvertebrate genomicsen_US
dc.subject.nhmsequence alignmenten_US
refterms.dateFOA2022-06-22T13:49:17Z


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