The evolution and changing ecology of the African hominid oral microbiome
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Authors
Fellows Yates, James AVelsko, Irina M
Aron, Franziska
Posth, Cosimo
Hofman, Courtney A
Austin, Rita M
Parker, Cody E
Mann, Allison E
Nägele, Kathrin
Arthur, Kathryn Weedman
Arthur, John W
Bauer, Catherine C
Crevecoeur, Isabelle
Cupillard, Christophe
Curtis, Matthew C
Dalén, Love
Díaz-Zorita Bonilla, Marta
Díez Fernández-Lomana, J Carlos
Drucker, Dorothée G
Escribano Escrivá, Elena
Francken, Michael
Gibbon, Victoria E
González Morales, Manuel R
Grande Mateu, Ana
Harvati, Katerina
Henry, Amanda G
Humphrey, Louise

Menéndez, Mario
Mihailović, Dušan
Peresani, Marco
Rodríguez Moroder, Sofía
Roksandic, Mirjana
Rougier, Hélène
Sázelová, Sandra
Stock, Jay T
Straus, Lawrence Guy
Svoboda, Jiří
Teßmann, Barbara
Walker, Michael J
Power, Robert C
Lewis, Cecil M
Sankaranarayanan, Krithivasan
Guschanski, Katerina
Wrangham, Richard W
Dewhirst, Floyd E
Salazar-García, Domingo C
Krause, Johannes
Herbig, Alexander
Warinner, Christina
Issue date
2021-05-18Subject Terms
dental calculusmicrobiome
Neanderthal
primate
salivary amylase
Metadata
Show full item recordAbstract
Significance The microbiome plays key roles in human health, but little is known about its evolution. We investigate the evolutionary history of the African hominid oral microbiome by analyzing dental biofilms of humans and Neanderthals spanning the past 100,000 years and comparing them with those of chimpanzees, gorillas, and howler monkeys. We identify 10 core bacterial genera that have been maintained within the human lineage and play key biofilm structural roles. However, many remain understudied and unnamed. We find major taxonomic and functional differences between the oral microbiomes of Homo and chimpanzees but a high degree of similarity between Neanderthals and modern humans, including an apparent Homo-specific acquisition of starch digestion capability in oral streptococci, suggesting microbial coadaptation with host diet.Citation
J.A. Fellows Yates, I.M. Velsko, F. Aron, C. Posth, C.A. Hofman, R.M. Austin, C.E. Parker, A.E. Mann, K. Nägele, K.W. Arthur, J.W. Arthur, C.C. Bauer, I. Crevecoeur, C. Cupillard, M.C. Curtis, L. Dalén, M. Díaz-Zorita Bonilla, J.C. Díez Fernández-Lomana, D.G. Drucker, E. Escribano Escrivá, M. Francken, V.E. Gibbon, M.R. González Morales, A. Grande Mateu, K. Harvati, A.G. Henry, L. Humphrey, M. Menéndez, D. Mihailović, M. Peresani, S. Rodríguez Moroder, M. Roksandic, H. Rougier, S. Sázelová, J.T. Stock, L.G. Straus, J. Svoboda, B. Teßmann, M.J. Walker, R.C. Power, C.M. Lewis, K. Sankaranarayanan, K. Guschanski, R.W. Wrangham, F.E. Dewhirst, D.C. Salazar-García, J. Krause, A. Herbig, C. Warinner, The evolution and changing ecology of the African hominid oral microbiome, Proc. Natl. Acad. Sci. U.S.A. 118 (20) e2021655118, https://doi.org/10.1073/pnas.2021655118 (2021).Type
Journal ArticleItem Description
Copyright © 2021 the Author(s). Published by PNAS. This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND). The attached file is the published version of the article.NHM Repository
ISSN
0027-8424EISSN
1091-6490ae974a485f413a2113503eed53cd6c53
10.1073/pnas.2021655118
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