Loading...
The Mitochondrial Genome of Toxocara canis
Jex, AR Hu, M Gasser, RB
Jex, AR
Hu, M
Gasser, RB
Citations
Altmetric:
Advisors
Editors
Other Contributors
Affiliation
EPub Date
Issue Date
2008-08-06
Submitted Date
2020-03-04
Subject Terms
Mitochondria
Nematoda
Ascaris
Cryptic speciation
Genetic epidemiology
Invertebrate genomics
Anisakis
Ribosomal RNA
Nematoda
Ascaris
Cryptic speciation
Genetic epidemiology
Invertebrate genomics
Anisakis
Ribosomal RNA
Collections
Files
Research Projects
Organizational Units
Journal Issue
Other Titles
Abstract
Toxocara canis (Ascaridida: Nematoda), which parasitizes (at the adult stage) the small intestine of canids, can be transmitted to a range of other mammals, including humans, and can cause the disease toxocariasis. Despite its significance as a pathogen, the genetics, epidemiology and biology of this parasite remain poorly understood. In addition, the zoonotic potential of related species of Toxocara, such as T. cati and T. malaysiensis, is not well known. Mitochondrial DNA is known to provide genetic markers for investigations in these areas, but complete mitochondrial genomic data have been lacking for T. canis and its congeners. In the present study, the mitochondrial genome of T. canis was amplified by long-range polymerase chain reaction (long PCR) and sequenced using a primer-walking strategy. This circular mitochondrial genome was 14162 bp and contained 12 protein-coding, 22 transfer RNA, and 2 ribosomal RNA genes consistent for secernentean nematodes, including Ascaris suum and Anisakis simplex (Ascaridida). The mitochondrial genome of T. canis provides genetic markers for studies into the systematics, population genetics and epidemiology of this zoonotic parasite and its congeners. Such markers can now be used in prospecting for cryptic species and for exploring host specificity and zoonotic potential, thus underpinning the prevention and control of toxocariasis in humans and other hosts.
Citation
Jex AR, Waeschenbach A, Littlewood DTJ, Hu M, Gasser RB (2008) The Mitochondrial Genome of Toxocara canis. PLoS Negl Trop Dis 2(8): e273. https://doi.org/10.1371/journal.pntd.0000273
Publisher
Journal
Research Unit
PubMed ID
PubMed Central ID
Embedded videos
Type
Journal Article
Item Description
© 2008 Jex et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The attached file is the published pdf.
NHM Repository
NHM Repository
Series/Report no.
ISSN
EISSN
1935-2735
ISBN
ISMN
GovDoc
Test Link
License
openAccess