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A genetic analysis of the Gibraltar Neanderthals
Bokelmann, Lukas Hajdinjak, Mateja Peyrégne, Stéphane Essel, Elena de Filippo, Cesare Glocke, Isabelle Grote, Steffi Mafessoni, Fabrizio Nagel, Sarah
Bokelmann, Lukas
Hajdinjak, Mateja
Peyrégne, Stéphane
Essel, Elena
de Filippo, Cesare
Glocke, Isabelle
Grote, Steffi
Mafessoni, Fabrizio
Nagel, Sarah
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2019-07-15
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Gibraltar neanderthal
Forbes' Quarry
paleogenetics
ancient DNA
library preparation
Forbes' Quarry
paleogenetics
ancient DNA
library preparation
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Abstract
The Forbes’ Quarry and Devil’s Tower partial crania from Gibraltar are among the first Neanderthal remains ever found. Here, we show that small amounts of ancient DNA are preserved in the petrous bones of the 2 individuals despite unfavorable climatic conditions. However, the endogenous Neanderthal DNA is present among an overwhelming excess of recent human DNA. Using improved DNA library construction methods that enrich for DNA fragments carrying deaminated cytosine residues, we were able to sequence 70 and 0.4 megabase pairs (Mbp) nuclear DNA of the Forbes’ Quarry and Devil’s Tower specimens, respectively, as well as large parts of the mitochondrial genome of the Forbes’ Quarry individual. We confirm that the Forbes’ Quarry individual was a female and the Devil’s Tower individual a male. We also show that the Forbes’ Quarry individual is genetically more similar to the ∼120,000-y-old Neanderthals from Scladina Cave in Belgium (Scladina I-4A) and Hohlenstein-Stadel Cave in Germany, as well as to a ∼60,000- to 70,000-y-old Neanderthal from Russia (Mezmaiskaya 1), than to a ∼49,000-y-old Neanderthal from El Sidrón (El Sidrón 1253) in northern Spain and other younger Neanderthals from Europe and western Asia. This suggests that the Forbes’ Quarry fossil predates the latter Neanderthals. The preservation of archaic human DNA in the warm coastal climate of Gibraltar, close to the shores of Africa, raises hopes for the future recovery of archaic human DNA from regions in which climatic conditions are less than optimal for DNA preservation.
Citation
L. Bokelmann,M. Hajdinjak,S. Peyrégne,S. Brace,E. Essel,C. de Filippo,I. Glocke,S. Grote,F. Mafessoni,S. Nagel,J. Kelso,K. Prüfer,B. Vernot,I. Barnes,S. Pääbo,M. Meyer,& C. Stringer, A genetic analysis of the Gibraltar Neanderthals, Proc. Natl. Acad. Sci. U.S.A. 116 (31) 15610-15615, https://doi.org/10.1073/pnas.1903984116 (2019).
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Copyright © 2019. Published under the PNAS license. The attached file is the published version of the article.
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0027-8424
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1091-6490
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openAccess