Reconstruction of the diapsid ancestral genome permits chromosome evolution tracing in avian and non-avian dinosaurs

Hdl Handle:
http://hdl.handle.net/10141/622371
Title:
Reconstruction of the diapsid ancestral genome permits chromosome evolution tracing in avian and non-avian dinosaurs
Authors:
O'Connor, RE; Romanov, MN; Kiazim, LG; Barrett, PM ( 0000-0003-0412-3000 ) ; Farré, M; Damas, J; Ferguson-Smith, M; Valenzuela, N; Larkin, DM; Griffin, DK
Citation:
TY - JOUR AU - O’Connor, Rebecca E. AU - Romanov, Michael N. AU - Kiazim, Lucas G. AU - Barrett, Paul M. AU - Farré, Marta AU - Damas, Joana AU - Ferguson-Smith, Malcolm AU - Valenzuela, Nicole AU - Larkin, Denis M. AU - Griffin, Darren K. PY - 2018 DA - 2018/05/21 TI - Reconstruction of the diapsid ancestral genome permits chromosome evolution tracing in avian and non-avian dinosaurs JO - Nature Communications SP - 1883 VL - 9 IS - 1 AB - Genomic organisation of extinct lineages can be inferred from extant chromosome-level genome assemblies. Here, we apply bioinformatic and molecular cytogenetic approaches to determine the genomic structure of the diapsid common ancestor. We then infer the events that likely occurred along this lineage from theropod dinosaurs through to modern birds. Our results suggest that most elements of a typical ‘avian-like’ karyotype (40 chromosome pairs, including 30 microchromosomes) were in place before the divergence of turtles from birds ~255 mya. This genome organisation therefore predates the emergence of early dinosaurs and pterosaurs and the evolution of flight. Remaining largely unchanged interchromosomally through the dinosaur–theropod route that led to modern birds, intrachromosomal changes nonetheless reveal evolutionary breakpoint regions enriched for genes with ontology terms related to chromatin organisation and transcription. This genomic structure therefore appears highly stable yet contributes to a large degree of phenotypic diversity, as well as underpinning adaptive responses to major environmental disruptions via intrachromosomal repatterning. SN - 2041-1723 UR - https://doi.org/10.1038/s41467-018-04267-9 DO - 10.1038/s41467-018-04267-9 ID - O’Connor2018
Journal:
NATURE COMMUNICATIONS
Issue date:
21-May-2018
URI:
http://hdl.handle.net/10141/622371
DOI:
10.1038/s41467-018-04267-9
Submitted date:
2018-05-31
Type:
Journal Article
Item Description:
The file attached is the Published/publisher’s pdf version of the article.; Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Subject Terms:
Comparative genomics; evolutionary biology; evolutionary genetics
ISSN:
2041-1723
Appears in Collections:
Earth sciences

Full metadata record

DC FieldValue Language
dc.contributor.authorO'Connor, REen
dc.contributor.authorRomanov, MNen
dc.contributor.authorKiazim, LGen
dc.contributor.authorBarrett, PMen
dc.contributor.authorFarré, Men
dc.contributor.authorDamas, Jen
dc.contributor.authorFerguson-Smith, Men
dc.contributor.authorValenzuela, Nen
dc.contributor.authorLarkin, DMen
dc.contributor.authorGriffin, DKen
dc.date.accessioned2018-06-05T14:24:00Z-
dc.date.available2018-06-05T14:24:00Z-
dc.date.issued2018-05-21en_US
dc.date.submitted2018-05-31-
dc.identifier.citationTY - JOUR AU - O’Connor, Rebecca E. AU - Romanov, Michael N. AU - Kiazim, Lucas G. AU - Barrett, Paul M. AU - Farré, Marta AU - Damas, Joana AU - Ferguson-Smith, Malcolm AU - Valenzuela, Nicole AU - Larkin, Denis M. AU - Griffin, Darren K. PY - 2018 DA - 2018/05/21 TI - Reconstruction of the diapsid ancestral genome permits chromosome evolution tracing in avian and non-avian dinosaurs JO - Nature Communications SP - 1883 VL - 9 IS - 1 AB - Genomic organisation of extinct lineages can be inferred from extant chromosome-level genome assemblies. Here, we apply bioinformatic and molecular cytogenetic approaches to determine the genomic structure of the diapsid common ancestor. We then infer the events that likely occurred along this lineage from theropod dinosaurs through to modern birds. Our results suggest that most elements of a typical ‘avian-like’ karyotype (40 chromosome pairs, including 30 microchromosomes) were in place before the divergence of turtles from birds ~255 mya. This genome organisation therefore predates the emergence of early dinosaurs and pterosaurs and the evolution of flight. Remaining largely unchanged interchromosomally through the dinosaur–theropod route that led to modern birds, intrachromosomal changes nonetheless reveal evolutionary breakpoint regions enriched for genes with ontology terms related to chromatin organisation and transcription. This genomic structure therefore appears highly stable yet contributes to a large degree of phenotypic diversity, as well as underpinning adaptive responses to major environmental disruptions via intrachromosomal repatterning. SN - 2041-1723 UR - https://doi.org/10.1038/s41467-018-04267-9 DO - 10.1038/s41467-018-04267-9 ID - O’Connor2018en
dc.identifier.issn2041-1723en_US
dc.identifier.doi10.1038/s41467-018-04267-9en_US
dc.identifier.urihttp://hdl.handle.net/10141/622371-
dc.relation.urihttps://www.nature.com/articles/s41467-018-04267-9?WT.ec_id=NCOMMS-20180523&spMailingID=56673545&spUserID=ODkwMTM2NjQyNgS2&spJobID=1403493766&spReportId=MTQwMzQ5Mzc2NgS2en_US
dc.rightsopenAccessen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleReconstruction of the diapsid ancestral genome permits chromosome evolution tracing in avian and non-avian dinosaursen_US
dc.typeJournal Article-
dc.identifier.journalNATURE COMMUNICATIONSen_US
dc.identifier.volume9en_US
pubs.organisational-group/Natural History Museum-
pubs.organisational-group/Natural History Museum/Science Group-
pubs.organisational-group/Natural History Museum/Science Group/Earth Sciences-
pubs.organisational-group/Natural History Museum/Science Group/Earth Sciences/Vertebrates and Anthropology Palaeobiology-
pubs.organisational-group/Natural History Museum/Science Group/Functional groups-
pubs.organisational-group/Natural History Museum/Science Group/Functional groups/Research-
dc.embargoNot knownen_US
elements.import.authorO'Connor, REen_US
elements.import.authorRomanov, MNen_US
elements.import.authorKiazim, LGen_US
elements.import.authorBarrett, PMen_US
elements.import.authorFarre, Men_US
elements.import.authorDamas, Jen_US
elements.import.authorFerguson-Smith, Men_US
elements.import.authorValenzuela, Nen_US
elements.import.authorLarkin, DMen_US
elements.import.authorGriffin, DKen_US
dc.description.nhmThe file attached is the Published/publisher’s pdf version of the article.en
dc.description.nhmOpen Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.-
dc.subject.nhmComparative genomics; evolutionary biology; evolutionary genetics-
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